Platelet-educated cancer cells and tumor-educated platelets: an egg-and-chicken debate
Platelets are versatile cells with known functions in hemostasis, thrombosis, inflammation, and several pathological...
Basic Mechanisms
Genetic and epigenetic factors in CAT
Cancer and thrombosis are associated with a vicious cycle in which cancer can amplify the risk of thrombosis, and...
Late-breaking research: relationship between PAI-1 cancer cell expression and thrombosis in pancreatic cancer
The urokinase plasminogen activator system is a serine protease family, including urokinase-type plasminogen activator...
Interplay between the hematologic system and solid tumor progression
A relationship between coagulation and cancer has been known since the 19th century, when Armand Trousseau first...
miRNA and its role in cancer-associated thrombosis
Cancer-associated thrombosis (CAT) is one of the leading causes of non-cancer-related deaths in patients with cancer...
Measurement of extracellular vesicles and their role in cancer-associated thrombosis
Extracellular vesicles (EV) are submicron vesicles released from activated cells, apoptotic cells and cancer cells...
Cancers as coagulant mosaics
Cancers are potent inducers of abnormal blood clotting, which usually heralds a more aggressive course of the disease...
Arterial Thromboembolism in Occult Cancer
In 1865, Armand Trousseau famously described unexplained thrombotic events as a first manifestation of occult...
Mouse models of cancer-associated thrombosis
Cancer patients have 4-7 fold increased risk of venous thromboembolism (VTE) compared with a general population ....
Disseminated Intravascular coagulation in solid and hematological cancers
Introduction There is a clear relationship between malignancy and deranged coagulation. Patients with cancer are at...