Measurement of extracellular vesicles and their role in cancer-associated thrombosis
Extracellular vesicles (EV) are submicron vesicles released from activated cells, apoptotic cells and cancer cells...
AUTHORS
Nigel Mackman
Professor of Medicine and Co-Director,Thrombosis and Hemostasis Progra, Department of Medicine, Division of Hematology/Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Dr Mackman received a PhD from the University of Leicester, UK. He then moved to The Scripps Research Institute in California (USA) as a postdoctoral fellow to study blood coagulation where he became an Associate Professor with tenure.
In 2007, Dr Mackman moved to the University of North Carolina at Chapel Hill (NC, USA) as a Professor in Medicine. In 2015, he received a Distinguished Scientist Award from the International Society of Thrombosis and Hemostasis, and in 2017, he received the ATVB Distinguished Achievement Award. Dr Mackman has served as an Associate Editor for Thrombosis & Hemostasis, the Journal of Thrombosis and Hemostasis, and the Journal of Clinical Investigation. He is currently a Senior Associate Editor for ATVB.
His research has focused on the roles of tissue factor, coagulation proteases, protease-activated receptors, extracellular vesicles, thrombosis, inflammation, ischemia–reperfusion injury, cancer, sickle cell disease, obesity, viral infection and atherosclerosis.
Dr Mackman received a PhD from the University of Leicester, UK. He then moved to The Scripps Research Institute in California (USA) as a postdoctoral fellow to study blood coagulation where he became an Associate Professor with tenure.
In 2007, Dr Mackman moved to the University of North Carolina at Chapel Hill (NC, USA) as a Professor in Medicine. In 2015, he received a Distinguished Scientist Award from the International Society of Thrombosis and Hemostasis, and in 2017, he received the ATVB Distinguished Achievement Award. Dr Mackman has served as an Associate Editor for Thrombosis & Hemostasis, the Journal of Thrombosis and Hemostasis, and the Journal of Clinical Investigation. He is currently a Senior Associate Editor for ATVB.
His research has focused on the roles of tissue factor, coagulation proteases, protease-activated receptors, extracellular vesicles, thrombosis, inflammation, ischemia–reperfusion injury, cancer, sickle cell disease, obesity, viral infection and atherosclerosis.
Mouse models of cancer-associated thrombosis
Cancer patients have 4-7 fold increased risk of venous thromboembolism (VTE) compared with a general population ....