Basic Mechanism

Arterial Thromboembolism in Occult Cancer
Basic Mechanism

Arterial Thromboembolism in Occult Cancer

In 1865, Armand Trousseau famously described unexplained thrombotic events as a first manifestation of occult malignancy. His documented cases mainly concerned venous thromboembolic events such as migratory thrombophlebitis...

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Mouse models of cancer-associated thrombosis
Basic Mechanism

Mouse models of cancer-associated thrombosis

The incidence of VTE is varied with cancer type, suggesting that there may be cancer-type specific mechanisms. However, the underlying mechanisms have not been elucidated. Mouse models are used to investigate the mechanisms of cancer-associated thrombosis. Many different mouse models have been established that vary by mouse strains, cancer cells, tumor sites and thrombosis models.

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Disseminated Intravascular coagulation in solid and hematological cancers
Basic Mechanism

Disseminated Intravascular coagulation in solid and hematological cancers

There is a clear relationship between malignancy and deranged coagulation. Patients with cancer are at high risk to present with venous thromboembolism, which occurrence in some cases may precede the diagnosis of cancer.

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The role of microparticles in VTE
Basic Mechanism

The role of microparticles in VTE

Cancer-associated venous thromboembolism (VTE) causes significant morbidity and mortality in patients and constitutes the second most common of death, after the progression of the cancer itself.

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