Nigel Mackman

Dr. Mackman began his scientific career studying the role of Escherichia coli hemolysin toxin in bacterial pathogenesis. He received a PhD from the University of Leicester, UK. In 1987, he moved to The Scripps Research Institute in California as a postdoctoral fellow to study blood coagulation and during his 20 years at the institute rose to the rank of Associate Professor with tenure. In 2007, Dr. Mackman moved to the University of North Carolina at Chapel Hill to become the John C. Parker Distinguished Professor in Medicine. He was the director of the UNC McAllister Heart Institute between 2011 and 2017. In 2015, he received a Distinguished Scientist Award from the International Society of Thrombosis and Hemostasis. In 2017, he received the ATVB Distinguished Achievement Award. Dr. Mackman has served as an Associate Editor for Thrombosis & Hemostasis, the Journal of Thrombosis and Hemostasis, and Journal of Clinical Investigation. He served as Associate Editor of ATVB between 2007 and 2012 and is currently a Senior Associate Editor for ATVB. His research has focused on the roles of tissue factor, coagulation proteases, protease activated receptors, extracellular vesicles, thrombosis, inflammation, ischemia-reperfusion injury, cancer, sickle cell disease, obesity, viral infection and atherosclerosis.

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Mouse models of cancer-associated thrombosis
Basic Mechanism

Mouse models of cancer-associated thrombosis

The incidence of VTE is varied with cancer type, suggesting that there may be cancer-type specific mechanisms. However, the underlying mechanisms have not been elucidated. Mouse models are used to investigate the mechanisms of cancer-associated thrombosis. Many different mouse models have been established that vary by mouse strains, cancer cells, tumor sites and thrombosis models.

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